Publications (Peer-reviewed)

• Takahashi T, Schleimer RP. Epithelial cell-derived extracellular vesicles in the pathophysiology of epithelial injury and repair in chronic rhinosinusitis: Connecting immunology in research lab to biomarkers in clinics Int J Mol Sci. 2021;22:11709. doi: 10.3390/.
• Takahashi T, Kato A, Berdnikovs S, Suh LA, Carter RG, Stevens WW, Price CP, Weibman AR, Norton JE, Harris KE, Peters AT, Grammer LC 3rd, Welch K, Shintani-Smith S, Conley DB, Tan BK, Kern RC, Schleimer RP. Integrin β6 microparticles in nasal lavage fluids; potential new biomarkers for basal cell activation in chronic rhinosinusitis Allergy. 2020;75 :3261-3264.
• Takahashi T, Kato A, Berdnikovs S, Stevens WW, Suh LA, Norton JE, Carter RG, Harris KE, Peters AT, Hulse KE, Grammer LC 3rd, Welch K, Shintani-Smith S, Tan BK, Conley DB, Kern RC, Bochner BS, Schleimer RP. Microparticles in nasal lavage fluids in chronic rhinosinusitis; potential biomarkers for diagnosis of Aspirin Exacerbated Respiratory Disease. J Allergy Clin Immunol. 2017;140:720-729.
• Ota C, Ishizawa K, Yamada M, Tando Y, He M, Takahashi T, Yamaya M, Yamamoto Y, Yamamoto H, Kure S, Kubo H. Receptor for advanced glycation end-products expressed on alveolar epithelial cells are the main target for hyperoxia-induced lung injury. Respir Investig. 2016; 54:98-108.
• Ota C, Yamada M, Fujino N, Motohashi H, Tando Y, Takei Y, Suzuki T, Takahashi T, Kamata S, Makiguchi T, Yamaya M, Kubo H. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. Exp Lung Res. 2015;41:422-34.
• Takahashi T, Kubo H. The role of microparticles in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014;9:303-314. eCollection 2014. Review.
• Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, Tando Y, Yamada M, Yanai M, Yamaya M, Kurosawa S, Yamauchi M, Kubo H. Annual FEV1 changes and numbers of circulating endothelial microparticles in COPD patients. BMJ Open. 2014;4:e004571. doi: 10.1136/bmjopen-2013-004571.
• Yamada M, Kubo H, Ota C, Takahashi T, Tando Y, Suzuki T, Fujino N, Makiguchi T, Takagi K, Suzuki T, Ichinose M. The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells. Respir Res. 2013 Sep 24;14:95.
• Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, Tando Y, Yamada M, Kurosawa S, Yamaya M, Kubo H. Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro. Exp Lung Res. 2013; 39:155-61.
• Fujino N, Kubo H, Ota C, Suzuki T, Takahashi T, Yamada M, Suzuki S, Kondo T, Nagatomi R, Tando Y, Yamaya M. Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis. J Infect Dis. 2013; 207:692-3.
• Fujino N, Ota C, Takahashi T, Suzuki T, Suzuki S, Yamada M, Nagatomi R, Kondo T, Yamaya M, Kubo H. Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case-control study. BMJ Open. 2:e001553, 2012.
• Fujino N, Ota C, Suzuki T, Suzuki S, Hegab AE, Yamada M, Takahashi T, He M, Kondo T, Kato H, Yamaya M, Kubo H. Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells. Resp Invest 2012; 50:110-6
• Takahashi T, Kubo H, Fujino N, Suzuki T, Ota C, Yamada M, Yamaya M, Suzuki S, Kurosawa S. Surgical stress increases circulating endothelial microparticles in the elderly. Anaesth Intensive Care. 2012;40:899-902
• Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H. Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility. Thorax.2012; 67:1067-74
• Fujino N, Kubo H, Suzuki T, He M, Suzuki T, Yamada M, Takahashi T, Ota C, Yamaya M. Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice. Exp Lung Res 38: 28-36, 2012.
• Fujino N, Kubo H, Ota C, Suzuki T, Suzuki S, Yamada M, Takahashi T, He M, Suzuki T, Kondo T, Yamaya M. A novel method for isolating individual cellular components from the adult human distal lung. Am J Respir Cell Mol Biol. 2012;46:422-30.
• Takahashi T, Suzuki S, Kubo H, Yamaya M, Kurosawa S, and Kato M. Impaired endothelial progenitor cell mobilization and colony-forming capacity in COPD. Respirology 2011; 16:680-7.